What should PaO2 be maintained at in the ARDS protocol?

In the context of managing Acute Respiratory Distress Syndrome (ARDS), the maintenance of arterial oxygen partial pressure (PaO2) at a target range of 55-80 mm Hg is vital for ensuring adequate tissue oxygenation while minimizing complications associated with oxygen toxicity and lung injury. The ARDSnet protocol specifically aims to prevent hyperoxia and maintain an optimal balance between oxygenation and the risks associated with high levels of oxygen.

This range is established based on clinical guidelines that advocate for sufficient oxygen levels to support cellular metabolism and function while avoiding excessively high oxygen concentrations which can lead to reactive oxygen species formation and further lung damage. Maintaining PaO2 within this range also helps to manage the patient's ventilation requirements and promotes more effective use of mechanical ventilation strategies applied in ARDS management.

Thus, setting a target of 55-80 mm Hg aligns with best practices in ARDS treatment, ensuring effective oxygen delivery while being cautious about potential adverse effects from high oxygen levels.